Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10222509 | 0.81 | SMN1; SMN2 (0.50) | MEN1KMT2ASMN1; SMN2LMNACRHBP | |
| SCHEMBL23031978 | 0.75 | CHRNB4 (0.40) | MEN1KMT2ASMN1; SMN2LMNACRHBP | |
| SCHEMBL12339882 | 0.71 | NPSR1 (0.47) | MEN1KMT2ASMN1; SMN2LMNACRHBP | |
| SCHEMBL10204116 | 0.70 | NOTUM (0.38) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL23872825 | 0.70 | NOTUM (0.38) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL406192 | 0.70 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2LMNACRHBP | |
| SCHEMBL16726437 | 0.69 | TSHR (0.33) | SMN1; SMN2L3MBTL1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL16726511 | 0.69 | TSHR (0.33) | SMN1; SMN2L3MBTL1ALDH1A1CHRNB4CHRNA3 | |
| SCHEMBL14228456 | 0.69 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2LMNACRHBP | |
| SCHEMBL10204114 | 0.68 | MEN1 (0.40) | MEN1KMT2ASMN1; SMN2GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278319-B2 | Substituted spiroamine compounds | GRUENENTHAL GMBH (DE) | 2012-10-02 | — | — | US | disclosed |
| US-20100113417-A1 | Substituted Spiroamine Compounds | GRUENENTHAL GMBH (DE) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113417-A1 | Substituted Spiroamine Compounds | BDKRB1, BDKRB2, REN | MEN1 346/4885KMT2A 1611/4885SMN1; SMN2 2529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.