Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 16/20 | 0.73 |
| ▸ | HSP90AA1 | P07900 | 16/20 | 0.73 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL384471 | 0.93 | HSP90AB1 (0.64) | HSP90AB1HSP90AA1HSP90B1NPC1TP53 | |
| SCHEMBL25216919 | 0.90 | HSP90AB1 (0.58) | HSP90AB1HSP90AA1HSP90B1NPC1TP53 | |
| SCHEMBL1018684 | 0.88 | HSP90AA1 (0.75) | HSP90AB1HSP90AA1HSP90B1ALKHDAC3 | |
| SCHEMBL1018432 | 0.88 | HSP90AA1 (0.80) | HSP90AB1HSP90AA1HSP90B1ALKHDAC3 | |
| SCHEMBL12855315 | 0.87 | HSP90AA1 (0.74) | HSP90AB1HSP90AA1HSP90B1HDAC3HDAC8 | |
| SCHEMBL1022760 | 0.86 | HSP90AA1 (0.73) | HSP90AB1HSP90AA1HSP90B1ALKHDAC3 | |
| SCHEMBL31363033 | 0.86 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1HSP90B1NPC1RAB9A | |
| SCHEMBL25317220 | 0.86 | HSP90AB1 (0.54) | HSP90AB1HSP90AA1HSP90B1NPC1TP53 | |
| SCHEMBL3377334 | 0.85 | HSP90AA1 (0.76) | HSP90AB1HSP90AA1HSP90B1ALKHDAC3 | |
| SCHEMBL25260723 | 0.85 | HSP90AA1 (0.54) | HSP90AB1HSP90AA1HSP90B1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8277807-B2 | Pharmaceutical combinations | ASTEX THERAPEUTICS LIMITED (GB) | 2012-10-02 | — | — | US | disclosed |
| US-20100092474-A1 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100092474-A1 | PHARMACEUTICAL COMBINATIONS | HSP90AB1, HEATR6, HEATR1 | HSP90AB1 1/4885HSP90AA1 4/4885HSP90B1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.