Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | FAP | Q12884 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | GRB2 | P62993 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PEPD | P12955 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12601319 | 0.83 | DPP4 (0.45) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL8246705 | 0.80 | DPP4 (0.43) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL8247400 | 0.80 | DPP4 (0.41) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL8249374 | 0.80 | DPP4 (0.41) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL8247918 | 0.76 | DPP4 (0.38) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL8253477 | 0.76 | DPP4 (0.38) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL8290468 | 0.75 | ELANE (0.44) | F2MEN1KMT2APRSS1 | |
| SCHEMBL8253104 | 0.74 | ELANE (0.47) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL8247440 | 0.74 | ELANE (0.50) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL12601475 | 0.74 | ELANE (0.39) | F2GRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664092-B1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORP (US) | 2011-02-02 | — | — | EP | disclosed |