Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.84 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.84 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.84 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.84 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.84 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.84 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.84 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.84 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.84 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.84 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.84 |
| ▸ | KDR | P35968 | 2/20 | 0.83 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.73 |
| ▸ | AURKA | O14965 | 1/20 | 0.73 |
| ▸ | INSR | P06213 | 1/20 | 0.73 |
| ▸ | FBP1 | P09467 | 1/20 | 0.73 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.73 |
| ▸ | FLT4 | P35916 | 1/20 | 0.73 |
| ▸ | CLK1 | P49759 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623 | 0.93 | EGFR (1.00) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8205022 | 0.91 | HDAC3 (1.00) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11727 | 0.91 | EGFR (1.00) | EGFRKDRERBB2AURKAINSR | |
| SCHEMBL1730545 | 0.91 | EGFR (1.00) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18435103 | 0.89 | EGFR (0.90) | EGFRKDRERBB2AURKAINSR | |
| SCHEMBL11113 | 0.89 | EGFR (1.00) | EGFRKDRERBB2AURKAINSR | |
| SCHEMBL18978997 | 0.89 | EGFR (0.89) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4343029 | 0.88 | EGFR (0.87) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10883 | 0.87 | EGFR (1.00) | EGFRKDRERBB2AURKAINSR | |
| SCHEMBL9925 | 0.87 | EGFR (1.00) | EGFRKDRERBB2AURKAINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1364212-B1 | THREE HYBRID ASSAY SYSTEM | GPC BIOTECH AG (DE) | 2011-02-02 | — | — | EP | disclosed |