Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.89 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.79 |
| ▸ | KDR | P35968 | 2/20 | 0.79 |
| ▸ | AURKA | O14965 | 1/20 | 0.79 |
| ▸ | INSR | P06213 | 1/20 | 0.79 |
| ▸ | FBP1 | P09467 | 1/20 | 0.79 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.79 |
| ▸ | FLT4 | P35916 | 1/20 | 0.79 |
| ▸ | CLK1 | P49759 | 1/20 | 0.79 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.79 |
| ▸ | TEK | Q02763 | 1/20 | 0.79 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.79 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.77 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.77 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.77 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4343029 | 0.99 | EGFR (0.87) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL1730545 | 0.94 | EGFR (1.00) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL13529196 | 0.92 | EGFR (0.98) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL30207668 | 0.91 | EGFR (0.85) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL14964773 | 0.91 | EGFR (0.85) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL31491085 | 0.91 | EGFR (0.85) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL14092460 | 0.91 | EGFR (0.92) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL28520911 | 0.91 | EGFR (0.85) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL31213839 | 0.90 | EGFR (0.84) | EGFRERBB2KDRAURKAINSR | |
| SCHEMBL5911655 | 0.90 | EGFR (0.86) | EGFRERBB2KDRAURKAINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181554-B1 | QUINAZOLINE DERIVATIVE | CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN) | 2020-10-28 | — | — | EP | disclosed |
| US-10774079-B2 | Quinazoline derivative | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2020-09-15 | — | — | US | disclosed |
| CN-106660970-B | Quinazoline derivatives | 石药集团中奇制药技术（石家庄）有限公司 | 2020-07-10 | — | — | CN | disclosed |
| US-10421754-B2 | Quinazoline derivative | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2019-09-24 | — | — | US | disclosed |
| US-20170226099-A1 | QUINAZOLINE DERIVATIVE | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2017-08-10 | — | — | US | disclosed |
| EP-3181554-A1 | QUINAZOLINE DERIVATIVE | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2017-06-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774079-B2 | Quinazoline derivative | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, TOP2A, TOP1 | EGFR 3701/4885ERBB2 2622/4885KDR 3669/4885 |
| US-10421754-B2 | Quinazoline derivative | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, TOP2A, TOP1 | EGFR 3701/4885ERBB2 2622/4885KDR 3669/4885 |
| US-20170226099-A1 | QUINAZOLINE DERIVATIVE | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, TOP2A, TOP1 | EGFR 3701/4885ERBB2 2622/4885KDR 3669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.