Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.77 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.77 |
| ▸ | JAK3 | P52333 | 2/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040833 | 0.87 | RAF1 (1.00) | RAF1PIK3C3JAK3JAK2ABL1 | |
| SCHEMBL5772199 | 0.87 | RAF1 (1.00) | RAF1PIK3C3JAK3JAK2ABL1 | |
| SCHEMBL5775600 | 0.77 | RAF1 (0.68) | RAF1PIK3C3JAK3JAK2ABL1 | |
| SCHEMBL5476260 | 0.77 | JAK3 (1.00) | RAF1PIK3C3JAK3JAK2ABL1 | |
| SCHEMBL5476263 | 0.77 | JAK3 (1.00) | RAF1PIK3C3JAK3JAK2ABL1 | |
| SCHEMBL6174867 | 0.75 | JAK3 (0.64) | RAF1PIK3C3JAK3JAK2ABL1 | |
| SCHEMBL5469456 | 0.74 | RET (1.00) | RAF1PIK3C3JAK3JAK2ABL1 | |
| SCHEMBL5469460 | 0.74 | RET (1.00) | RAF1PIK3C3JAK3JAK2ABL1 | |
| SCHEMBL6742300 | 0.74 | PLK4 (0.58) | RAF1PIK3C3JAK3JAK2ABL1 | |
| SCHEMBL6742302 | 0.74 | PLK4 (0.58) | RAF1PIK3C3JAK3JAK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1364212-B1 | THREE HYBRID ASSAY SYSTEM | GPC BIOTECH AG (DE) | 2011-02-02 | — | — | EP | disclosed |