Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 12/20 | 0.52 |
| ▸ | NOS1 | P29475 | 12/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.52 |
| ▸ | NOS2 | P35228 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | HTR1D | P28221 | 8/20 | 0.47 |
| ▸ | HTR1B | P28222 | 8/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1F | P30939 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13849967 | 0.90 | NOS3 (0.65) | NOS3NOS1SLC6A2NOS2CYP3A4 | |
| SCHEMBL13846440 | 0.90 | NOS3 (0.65) | NOS3NOS1SLC6A2NOS2CYP3A4 | |
| SCHEMBL12305810 | 0.90 | NOS3 (0.65) | NOS3NOS1SLC6A2NOS2CYP3A4 | |
| SCHEMBL1122075 | 0.90 | NOS3 (0.65) | NOS3NOS1SLC6A2NOS2CYP3A4 | |
| SCHEMBL13846432 | 0.89 | NOS3 (0.49) | NOS3NOS1SLC6A2NOS2CYP3A4 | |
| SCHEMBL14178968 | 0.89 | NOS3 (0.64) | NOS3NOS1SLC6A2NOS2CYP3A4 | |
| SCHEMBL1122115 | 0.89 | NOS3 (0.64) | NOS3NOS1SLC6A2NOS2CYP3A4 | |
| SCHEMBL1122146 | 0.88 | NOS3 (0.61) | NOS3NOS1SLC6A2NOS2CYP3A4 | |
| SCHEMBL1122005 | 0.88 | HTR1D (0.64) | NOS3NOS1NOS2CYP3A4CYP2D6 | |
| SCHEMBL1122042 | 0.87 | NOS3 (0.66) | NOS3NOS1SLC6A2NOS2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1883451-B9 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON INC (CA) | 2011-02-09 | — | — | EP | disclosed |
| EP-1883451-B1 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON INC (CA) | 2010-11-24 | — | — | EP | disclosed |
| US-20090131503-A1 | 3,5 - SUBSTITUTED INDOLE COMPOUNDS HAVING NOS AND NOREPINEPHRINE REUPTAKE INHIBITORY ACTIVITY | NEURAXON, INC (CA) | 2009-05-21 | — | — | US | disclosed |
| WO-2007063418-A2 | SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2007-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131503-A1 | 3,5 - SUBSTITUTED INDOLE COMPOUNDS HAVING NOS AND NOREPINEPHRINE REUPTAKE INHIBITORY ACTIVITY | SLC6A2, AANAT, NOS3 | NOS3 3/4885NOS1 5/4885SLC6A2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.