AANAT — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6424908	1.00	1/20
SCHEMBL4536522	0.80	1/20
SCHEMBL5903804	0.77	1/20
SCHEMBL7677886	0.77	1/20
SCHEMBL10069200	0.77	1/20
SCHEMBL761155	0.75	1/20
SCHEMBL6424904	0.75	1/20
SCHEMBL6703004	0.75	1/20
SCHEMBL20227977	0.75	1/20
SCHEMBL2440677	0.74	1/20
SCHEMBL761481	0.73	1/20
Hydrochloric Acid (SCHEMBL3826492)	0.73	1/20
SCHEMBL19051489	0.73	1/20
SCHEMBL6394942	0.72	1/20
SCHEMBL918964	0.71	1/20
SCHEMBL918966	0.71	1/20
SCHEMBL9118459	0.71	1/20
SCHEMBL176107	0.70	1/20
Nb-Acetyltryptamine (SCHEMBL468850)	0.70	1/20
SCHEMBL627038	0.70	1/20

Clinical trials — most relevant to AANAT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Study of add-on Ramelteon Therapy on Sleep and Circadian Rhythm Disruption in Patients With Schizophrenia	PHASE4	COMPLETED
Effect of Topical Melatonin Application on Dental Implant Osseointegration and Marginal Bone Level	PHASE3	UNKNOWN
A Trial of CM-AT in Children With Autism With All Levels of FCT (The Blum Study)	PHASE3	COMPLETED
Aripiprazole Effects on Alcohol Drinking and Craving	PHASE3	COMPLETED
5HT2CR Balance in Brain Connectivity in Cocaine Dependence	PHASE1/PHASE2	COMPLETED
Sirtuin-NAD Activator in Alzheimer's Disease	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Modafinil vs Placebo for the Treatment of Methamphetamine Dependence	PHASE2	COMPLETED
A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A)	EARLY_PHASE1	COMPLETED
Melatonin in Pregnancy	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke	nan	COMPLETED
The Effects of Dextroamphetamine on Brain Function	nan	COMPLETED
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder	nan	UNKNOWN
Polymorphisms, Caffeine and Sleep Disorders	nan	COMPLETED
Estrogen Receptor 1 Gene Polymorphism Frequency in Fibromyalgia Syndrome	nan	COMPLETED
Pharmacogenomics of Antidepressant Response in Children and Adolescents	nan	COMPLETED
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy.	nan	UNKNOWN
Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)	nan	COMPLETED
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
The Genetic Basis for Vulnerability to Substance Abuse	nan	COMPLETED
Melatonin for Knee Osteoarthritis Patients	nan	COMPLETED
Influence of Caffeine Consumption on the Human Circadian System	nan	COMPLETED
The Synergistic Effects of AIH and FES in Persons With MS	nan	ACTIVE_NOT_RECRUITING
The Association Between Executive Functions and Candidate Genes of Dopaminergic and Noradrenergic Systems in Attention Deficit Hyperactivity Disorder (ADHD)	nan	COMPLETED
Serotonergic System and Violent Video Games	nan	COMPLETED
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Molecular Studies on the Candidate Genes of Dopaminergic and Noradrenergic Systems in ADHD	nan	COMPLETED
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients	nan	UNKNOWN
Screening Evaluation for Studies of the National Institute on Alcohol Abuse and Alcoholism (NIAAA)	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a AANAT binder may also engage these)

Protein	Name	Similarity
O97756	—	1.000	O97756 →
Q5IS55	—	1.000	Q5IS55 →
O02785	—	0.996	O02785 →
O88816	—	0.996	O88816 →
Q29495	—	0.992	Q29495 →
Q64666	—	0.989	Q64666 →
Q9R0A9	—	0.987	Q9R0A9 →
P79774	—	0.978	P79774 →
O43304	—	0.970	O43304 →
Q9R011	—	0.969	Q9R011 →
RAPGEF3	Rap guanine nucleotide exchange factor 3	0.966	landscape →
Q6VY05	—	0.966	Q6VY05 →
P0DPE0	—	0.965	P0DPE0 →
DCLRE1B	5' exonuclease Apollo	0.964	landscape →
P10938	—	0.964	P10938 →
D4ABH7	—	0.964	D4ABH7 →
BCDIN3D	RNA 5'-monophosphate methyltransferase	0.964	landscape →
Q8VC33	—	0.963	Q8VC33 →
MAP3K6	Mitogen-activated protein kinase kinase kinase 6	0.963	landscape →
Q9QZC5	—	0.963	Q9QZC5 →
D2H8V8	—	0.963	D2H8V8 →
Q8C7W7	—	0.963	Q8C7W7 →
Q8C5V5	—	0.963	Q8C5V5 →
E6ZIJ1	—	0.963	E6ZIJ1 →
Q99KF0	—	0.962	Q99KF0 →
Q9BXL6	—	0.962	Q9BXL6 →
P10937	—	0.962	P10937 →
Q8VCC8	—	0.962	Q8VCC8 →
Q4KLY6	—	0.962	Q4KLY6 →
Q86UT6	—	0.962	Q86UT6 →