Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.59 |
| ▸ | IKBKB | O14920 | 3/20 | 0.59 |
| ▸ | RAF1 | P04049 | 3/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.59 |
| ▸ | AKT1 | P31749 | 3/20 | 0.59 |
| ▸ | AKT2 | P31751 | 3/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.59 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.59 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.59 |
| ▸ | NEK1 | Q96PY6 | 3/20 | 0.59 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.59 |
| ▸ | PRDX1 | Q06830 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21067541 | 0.78 | MAPK1 (0.56) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL1247436 | 0.77 | MTOR (0.64) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL1247438 | 0.77 | MTOR (0.64) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL8173602 | 0.75 | MTOR (0.65) | GSK3BMTORRPTORMLST8 | |
| SCHEMBL8173600 | 0.75 | MTOR (0.65) | GSK3BMTORRPTORMLST8 | |
| SCHEMBL21460535 | 0.75 | IKBKB (1.00) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL21460534 | 0.75 | IKBKB (1.00) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL29794510 | 0.75 | IKBKB (1.00) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL8106620 | 0.75 | IKBKB (1.00) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL15281015 | 0.74 | PIM1 (0.55) | MAPK1AKT1AKT2SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034458-A1 | PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034458-A1 | PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS | PIK3CD, PIK3CA, PTEN | MAPK1 246/4885IKBKB 1462/4885RAF1 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.