Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 10/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138764 | 1.00 | NR1H4 (0.43) | NR1H4MMP1MRGPRX4KEAP1NFE2L2 | |
| SCHEMBL12863735 | 0.92 | KEAP1 (0.40) | MRGPRX4KEAP1NFE2L2RXRARXRB | |
| SCHEMBL1138805 | 0.92 | KEAP1 (0.40) | MRGPRX4KEAP1NFE2L2RXRARXRB | |
| SCHEMBL1139357 | 0.85 | RXRA (0.50) | MRGPRX4KEAP1NFE2L2RXRARXRB | |
| SCHEMBL2735695 | 0.83 | KEAP1 (0.41) | KEAP1NFE2L2RXRARXRBRXRG | |
| SCHEMBL1138745 | 0.83 | KEAP1 (0.41) | KEAP1NFE2L2RXRARXRBRXRG | |
| SCHEMBL1138631 | 0.80 | AKR1C3 (0.45) | KEAP1NFE2L2 | |
| SCHEMBL12863465 | 0.80 | AKR1C3 (0.45) | KEAP1NFE2L2 | |
| SCHEMBL1139554 | 0.80 | KDM4E (0.42) | MRGPRX4KEAP1NFE2L2RXRARXRB | |
| SCHEMBL1139450 | 0.80 | KDM4E (0.42) | MRGPRX4KEAP1NFE2L2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0947500-B1 | SULFONAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2011-02-23 | — | — | EP | disclosed |