Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21726747 | 0.83 | KCNH2 (0.43) | ALDH1A1MEN1KMT2AKDM4ETSHR | |
| SCHEMBL1286810 | 0.82 | HRH3 (0.50) | ALDH1A1MEN1KMT2APOLBLMNA | |
| SCHEMBL2798328 | 0.82 | MEN1 (0.53) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL29572349 | 0.82 | MEN1 (0.53) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL2796930 | 0.81 | MAPT (0.41) | ALDH1A1POLBLMNATSHR | |
| SCHEMBL1286789 | 0.81 | HPGD (0.53) | ALDH1A1ACHEKDM4ECHRM2CHRM3 | |
| SCHEMBL9566374 | 0.78 | MEN1 (0.48) | GAAALDH1A1MEN1KMT2APOLB | |
| SCHEMBL6973124 | 0.78 | GAA (0.73) | GAAALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9897988 | 0.76 | BLM (0.52) | BLMALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4523309 | 0.76 | SIGMAR1 (0.56) | GAAALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |