Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286799 | 0.81 | BLM (0.48) | ALDH1A1ACHETSHRKDM4ECHRM2 | |
| SCHEMBL21726745 | 0.78 | KMT2A (0.42) | ALDH1A1TSHRHRH3 | |
| SCHEMBL21726748 | 0.78 | KMT2A (0.42) | ALDH1A1TSHRHRH3 | |
| SCHEMBL14812968 | 0.78 | CYP3A4 (0.57) | HPGDALDH1A1TP53TSHRUSP2 | |
| SCHEMBL1286820 | 0.78 | HRH3 (0.59) | ALDH1A1TP53TSHRHRH3USP2 | |
| SCHEMBL1709223 | 0.76 | POLB (0.50) | HPGDALDH1A1TSHR | |
| SCHEMBL22615930 | 0.76 | HRH3 (0.40) | HRH3 | |
| SCHEMBL15655020 | 0.76 | HRH3 (0.40) | HRH3 | |
| SCHEMBL3977397 | 0.76 | HPGD (0.58) | HPGDALDH1A1TP53ACHETSHR | |
| SCHEMBL6233435 | 0.76 | HPGD (0.58) | HPGDALDH1A1TP53ACHESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |