Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | CCKAR | P32238 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709229 | 0.81 | SCN9A (0.49) | KMT2AMMP3HDAC8SCN9APLK1 | |
| SCHEMBL1709219 | 0.81 | SCN9A (0.74) | KMT2AMMP3HDAC8SCN9ADRD4 | |
| SCHEMBL1709207 | 0.79 | SCN9A (0.54) | KMT2AMMP3HDAC8SCN9ADRD4 | |
| SCHEMBL18838296 | 0.78 | EZH2 (0.45) | KMT2AHDAC8SCN9A | |
| SCHEMBL10072168 | 0.78 | SCN9A (0.56) | KMT2AMMP3HDAC8SCN9ADRD4 | |
| SCHEMBL10071958 | 0.78 | DRD4 (0.67) | SCN9ADRD4 | |
| SCHEMBL1286845 | 0.77 | SCN9A (0.66) | KMT2AMMP3HDAC8SCN9ADRD4 | |
| SCHEMBL1709262 | 0.77 | SCN9A (0.52) | KMT2AMMP3HDAC8SCN9ADRD4 | |
| SCHEMBL10072166 | 0.77 | SCN9A (0.60) | KMT2AMMP3HDAC8SCN9ADRD4 | |
| SCHEMBL31074994 | 0.77 | KMT2A (0.61) | KMT2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |