Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 5/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286815 | 0.81 | KMT2A (0.55) | SCN9AKMT2AMMP3HDAC8DRD4 | |
| SCHEMBL1709219 | 0.80 | SCN9A (0.74) | SCN9AKMT2AMMP3HDAC8DRD4 | |
| SCHEMBL1709207 | 0.78 | SCN9A (0.54) | SCN9AKMT2AMMP3HDAC8DRD4 | |
| SCHEMBL10071958 | 0.77 | DRD4 (0.67) | SCN9ADRD4 | |
| SCHEMBL1709262 | 0.77 | SCN9A (0.52) | SCN9AKMT2AMMP3HDAC8DRD4 | |
| SCHEMBL10072168 | 0.75 | SCN9A (0.56) | SCN9AKMT2AMMP3HDAC8DRD4 | |
| SCHEMBL1709274 | 0.75 | ALDH1A1 (0.53) | SCN9AKMT2ADRD4 | |
| SCHEMBL1286845 | 0.74 | SCN9A (0.66) | SCN9AKMT2AMMP3HDAC8DRD4 | |
| SCHEMBL1709263 | 0.73 | SCN9A (0.53) | SCN9AKMT2AMMP3HDAC8DRD4 | |
| SCHEMBL1709222 | 0.72 | SCN9A (0.60) | SCN9AKMT2AMMP3HDAC8DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |