SCHEMBL12868356

SCHEMBL12868356

Cc1cc(C(=O)C(C)(C)C)nn1C

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
BAZ2B Q9UIF8 1/20 0.58
KDM4E B2RXH2 6/20 0.41
RAB9A P51151 3/20 0.41
GAA P10253 3/20 0.41
KMT2A Q03164 1/20 0.41
NR2E1 Q9Y466 2/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
NPC1 O15118 2/20 0.38
HTR2A P28223 1/20 0.37
GRN P28799 1/20 0.37
SORT1 Q99523 1/20 0.37
ROCK1 Q13464 1/20 0.35
MGLL Q99685 1/20 0.34
TNF P01375 1/20 0.34
POLB P06746 1/20 0.34
NR2F2 P24468 1/20 0.34
NOD1 Q9Y239 1/20 0.34
BCHE P06276 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27787704 0.79 BAZ2B (0.66) BAZ2BKDM4ERAB9AGAAKMT2A
SCHEMBL357627 0.78 BAZ2B (0.63) BAZ2BKDM4ERAB9AGAAKMT2A
SCHEMBL222289 0.78 BAZ2B (0.63) BAZ2BKDM4ERAB9AGAAKMT2A
SCHEMBL25815441 0.77 BAZ2B (0.53) BAZ2BKDM4ERAB9AGAAKMT2A
SCHEMBL12083938 0.77 BAZ2B (0.53) BAZ2BKDM4ERAB9AGAAKMT2A
SCHEMBL2757921 0.77 BAZ2B (0.67) BAZ2BKDM4ERAB9AGAAKMT2A
SCHEMBL1080282 0.76 BAZ2B (0.61) BAZ2BKDM4ERAB9AGAAKMT2A
SCHEMBL1555279 0.76 BAZ2B (0.61) BAZ2BKDM4ERAB9AGAAKMT2A
SCHEMBL193910 0.76 BAZ2B (0.61) BAZ2BKDM4ERAB9AGAAKMT2A
SCHEMBL25552307 0.75 AURKA (0.38) BAZ2BKDM4EKMT2AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144890-A1 ANTIBODY DRUG CONJUGATE COMPRISING NMT INHIBITOR CONJUGATED TO AN ANTIBODY MyricX Pharma Limited (GB) 2026-05-28 US disclosed
EP-4741393-A2 NOVEL COMPOUNDS AND THEIR USE IN THERAPY MyricX Pharma Limited (GB) 2026-05-13 EP disclosed
US-12599676-B2 Cytotoxic imidazo[1,2-A]pyridine compounds and their use in therapy MyricX Pharma Limited (GB) 2026-04-14 US disclosed
US-20260083858-A1 ANTIBODY DRUG CONJUGATE COMPRISING NMT INHIBITOR AND ITS USE MYRICX PHARMA LTD (GB) 2026-03-26 US disclosed
EP-4707278-A2 NOVEL COMPOUNDS AND THEIR USE IN THERAPY MyricX Pharma Limited (GB) 2026-03-11 EP disclosed
US-20260048136-A1 CYTOTOXIC IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY MYRICX PHARMA LTD (GB) 2026-02-19 US disclosed
US-20260049075-A1 CYTOTOXIC IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY MYRICX PHARMA LTD (GB) 2026-02-19 US disclosed
EP-4583979-A1 CYTOTOXIC IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY MyricX Pharma Limited (GB) 2025-07-16 EP disclosed
EP-4583919-A1 ANTIBODY DRUG CONJUGATE COMPRISING NMT INHIBITOR AND ITS USE MyricX Pharma Limited (GB) 2025-07-16 EP disclosed
CN-119997982-A Antibody drug conjugates comprising NMT inhibitors and uses thereof 迈里克斯制药有限公司 2025-05-13 CN disclosed
CN-119968369-A Cytotoxic imidazo [1,2-a ] pyridine compounds and their use in therapy 迈里克斯制药有限公司 2025-05-09 CN disclosed
WO-2024052685-A1 CYTOTOXIC IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY MyricX Pharma Limited (GB) 2024-03-14 WO disclosed
WO-2024052684-A1 ANTIBODY DRUG CONJUGATE COMPRISING NMT INHIBITOR AND ITS USE MyricX Pharma Limited (GB) 2024-03-14 WO disclosed
WO-2024052685-A1 CYTOTOXIC IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY MyricX Pharma Limited (GB) 2024-03-14 WO disclosed
US-20140329836-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF MILLENNIUM PHARMACEUTICALS, INC. (US) 2014-11-06 US disclosed
US-8624040-B2 Substituted hydroxamic acids and uses thereof MILLENNIUM PHARMACEUTICALS, INC. (US) 2014-01-07 US disclosed
US-20110046157-A1 Substituted hydroxamic acids and uses thereof MILLENNIUM PHARMACEUTICALS, INC. (US) 2011-02-24 US disclosed
US-20090137601-A1 L-Phenylalanine Derivatives ASTRAZENECA AB (SE) 2009-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140329836-A1 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF HDAC6, HDAC5, HDAC1 BAZ2B 171/4885KDM4E 903/4885RAB9A 2388/4885
US-20260083858-A1 ANTIBODY DRUG CONJUGATE COMPRISING NMT INHIBITOR AND ITS USE NMT1, CSGALNACT1, NMT2 BAZ2B 3057/4885KDM4E 2098/4885RAB9A 959/4885
US-20260049075-A1 CYTOTOXIC IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY XPA, FLT3, TPMT BAZ2B 4062/4885KDM4E 1532/4885RAB9A 1696/4885
US-20260048136-A1 CYTOTOXIC IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AND THEIR USE IN THERAPY SLC7A1, FLT3, ABL1 BAZ2B 4524/4885KDM4E 2143/4885RAB9A 1210/4885
US-12599676-B2 Cytotoxic imidazo[1,2-A]pyridine compounds and their use in therapy ABL1, FLT3, MTX2 BAZ2B 4541/4885KDM4E 2699/4885RAB9A 1057/4885
US-20110046157-A1 Substituted hydroxamic acids and uses thereof HDAC6, HDAC5, HDAC1 BAZ2B 171/4885KDM4E 903/4885RAB9A 2388/4885
US-20260144890-A1 ANTIBODY DRUG CONJUGATE COMPRISING NMT INHIBITOR CONJUGATED TO AN ANTIBODY TOP1, NMT1, NMT2 BAZ2B 3253/4885KDM4E 1668/4885RAB9A 1909/4885
US-20090137601-A1 L-Phenylalanine Derivatives ITGB5, ITGB1, ITGA2B BAZ2B 2013/4885KDM4E 2743/4885RAB9A 2565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.