Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287034 | 0.91 | OPRK1 (0.34) | OPRK1CYP2D6DPP4METAP2HRH3 | |
| SCHEMBL1287090 | 0.84 | OPRK1 (0.31) | OPRK1GAA | |
| Hydrochloric Acid SCHEMBL1287023 | 0.79 | OPRK1 (0.37) | OPRK1 | |
| SCHEMBL3073995 | 0.79 | OPRK1 (0.35) | OPRK1TP53GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL1287037 | 0.78 | OPRK1 (0.50) | OPRK1TP53GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL1287096 | 0.77 | OPRK1 (0.30) | OPRK1 | |
| SCHEMBL1287003 | 0.76 | OPRK1 (0.41) | OPRK1TP53GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL587150 | 0.75 | OPRK1 (0.33) | OPRK1TP53GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL1287035 | 0.74 | OPRK1 (0.49) | OPRK1TP53SMN1; SMN2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL1287022 | 0.74 | DPP4 (0.31) | OPRK1TP53DPP4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047156-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS PLASMINOGEN INHIBITORS AND THEIR USE IN THE TREATMENT OF FIBRINOLYSIS RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-04-12 | — | — | WO | disclosed |