Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 3/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580791 | 0.95 | BRD4 (0.34) | BRD4CREBBPIL1BP2RX7EPHX2 | |
| SCHEMBL3073995 | 0.95 | OPRK1 (0.35) | OPRK1IL1BP2RX7ALDH1A1MAPT | |
| SCHEMBL586873 | 0.82 | IL1B (0.30) | IL1BP2RX7 | |
| SCHEMBL581808 | 0.81 | ALDH1A1 (0.39) | BRD4CREBBPALDH1A1MAPTHSD17B10 | |
| SCHEMBL581649 | 0.80 | GAA (0.32) | IL1BP2RX7ALDH1A1MAPTGAA | |
| SCHEMBL582194 | 0.80 | GAA (0.32) | IL1BP2RX7ALDH1A1MAPTGAA | |
| SCHEMBL3078365 | 0.80 | GAA (0.32) | IL1BP2RX7ALDH1A1MAPTGAA | |
| SCHEMBL1287034 | 0.75 | OPRK1 (0.34) | OPRK1 | |
| SCHEMBL1287102 | 0.75 | OPRK1 (0.42) | OPRK1ALDH1A1MAPTNPSR1HPGD | |
| SCHEMBL580419 | 0.73 | RAB9A (0.37) | ALDH1A1MAPTNPSR1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |