Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287178 | 0.84 | TSHR (0.47) | POLBKMT2AMEN1LMNAMAPT | |
| SCHEMBL6302799 | 0.78 | CA12 (0.38) | HTTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL21753522 | 0.77 | TDP1 (0.46) | TDP1POLBAPEX1KDM4EHTT | |
| SCHEMBL16154079 | 0.76 | TDP1 (0.49) | TDP1POLBAPEX1KDM4EHTT | |
| SCHEMBL16144858 | 0.76 | TDP1 (0.51) | TDP1POLBAPEX1KDM4EHTT | |
| SCHEMBL1626240 | 0.75 | TDP1 (0.54) | TDP1POLBAPEX1KDM4EPPARG | |
| SCHEMBL8234154 | 0.75 | HTT (0.54) | TDP1POLBAPEX1KDM4EHTT | |
| SCHEMBL14847452 | 0.74 | PPARG (0.52) | TDP1POLBAPEX1KDM4EEPHX2 | |
| SCHEMBL24404139 | 0.74 | HPGD (0.43) | TDP1HTTKMT2AMEN1LMNA | |
| SCHEMBL21572813 | 0.74 | HPGD (0.43) | TDP1HTTKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047993-A2 | N-HYDROXYPYRIMIDINE-2,4-DIONES AS INHIBITORS OF HIV AND HCV | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2012-04-12 | — | — | WO | disclosed |