Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653111 | 0.79 | TDP1 (0.63) | TDP1KDM4EEPHX2PPARGPOLB | |
| SCHEMBL21753573 | 0.79 | RAB9A (0.41) | TDP1KDM4EEPHX2PPARGPOLB | |
| SCHEMBL1287236 | 0.77 | TDP1 (0.45) | TDP1KDM4EEPHX2PPARGPOLB | |
| SCHEMBL16144858 | 0.73 | TDP1 (0.51) | TDP1KDM4EPOLBAPEX1RAB9A | |
| SCHEMBL1626240 | 0.73 | TDP1 (0.54) | TDP1KDM4EPPARGPOLBAPEX1 | |
| SCHEMBL3411918 | 0.72 | CA12 (0.63) | TDP1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL839736 | 0.71 | PPARG (0.51) | TDP1KDM4EEPHX2PPARGPOLB | |
| SCHEMBL699965 | 0.71 | KDM4E (0.50) | TDP1KDM4EPOLBAPEX1RAB9A | |
| SCHEMBL1064642 | 0.71 | PPARG (0.51) | TDP1KDM4EEPHX2PPARGPOLB | |
| SCHEMBL838697 | 0.71 | PPARG (0.51) | TDP1KDM4EEPHX2PPARGPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020038460-A1 | NOVEL QUINOLINE DERIVATIVE INHIBITOR | 南京药捷安康生物科技有限公司 | 2020-02-27 | — | — | WO | disclosed |