SCHEMBL1287178

SCHEMBL1287178

CCOC(=O)C(C(=O)Cc1ccccc1)C(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
LMNA P02545 2/20 0.47
MMP8 P22894 2/20 0.47
PIN1 Q13526 1/20 0.45
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
NPC1 O15118 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
ALDH1A1 P00352 4/20 0.43
POLB P06746 2/20 0.43
HSD17B10 Q99714 1/20 0.43
MAPK8 P45983 1/20 0.43
MAPK9 P45984 1/20 0.43
MAPK10 P53779 1/20 0.43
RECQL P46063 1/20 0.42
MAPT P10636 1/20 0.42
MAPK1 P28482 1/20 0.42
CTSB P07858 1/20 0.42
CES2 O00748 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1287236 0.84 TDP1 (0.45) TSHRLMNAMEN1KMT2ASMN1; SMN2
SCHEMBL16050421 0.84 L3MBTL1 (0.49) L3MBTL1LMNAMMP8PIN1MEN1
SCHEMBL5330174 0.83 TSHR (0.50) TSHRL3MBTL1LMNAMMP8PIN1
SCHEMBL4780675 0.82 ALOX5 (0.50) L3MBTL1LMNANPC1SMN1; SMN2MAPT
SCHEMBL13495167 0.81 MMP8 (0.50) TSHRL3MBTL1LMNAMMP8PIN1
SCHEMBL7758062 0.81 TSHR (0.50) TSHRMEN1KMT2ANPC1POLB
SCHEMBL18953827 0.81 GAA (0.46) TSHRL3MBTL1LMNAPIN1MEN1
SCHEMBL6302799 0.81 CA12 (0.38) TSHRL3MBTL1LMNAPIN1MEN1
SCHEMBL3690028 0.79 MMP8 (0.48) TSHRL3MBTL1LMNAMMP8PIN1
SCHEMBL16049191 0.79 MMP8 (0.55) TSHRL3MBTL1LMNAMMP8PIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107778254-A The synthetic method of the pyrimidine derivatives of Internmediate of anti viral medicine oxo two 陈国妃 2018-03-09 CN disclosed
WO-2012047993-A2 N-HYDROXYPYRIMIDINE-2,4-DIONES AS INHIBITORS OF HIV AND HCV REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2012-04-12 WO disclosed
EP-1557197-A1 Dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity Parker Hughes Institute (US) 2005-07-27 EP disclosed
US-6452006-B1 USED AS INTERMEDIATE IN THE SYNTHESIS OF ACTIVE COMPOUNDS WHICH ARE INHIBITORS OF HIV (HUMAN IMMUNODEFICIENCY VIRUS) REVERSE TRANSCRIPTASE SYLACHIM (FR) 2002-09-17 US disclosed
CN-1352637-A Process for preparing MKC-442 TRIANGLE PHARMACEUTICALS INC (US) 2002-06-05 CN disclosed
US-6376504-B1 NON-NUCLEOSIDE RETROVIRUS INHIBITORS WITH SPERMICIDAL ACTIVITY PARKER HUGHES INSTITUTE 2002-04-23 US disclosed
EP-1169310-A1 PROCESS FOR PREPARING MKC-442 Triangle Pharmaceuticals Inc. (US) 2002-01-09 EP disclosed
EP-1169310-A1 PROCESS FOR PREPARING MKC-442 Triangle Pharmaceuticals Inc. (US) 2002-01-09 EP disclosed
EP-1140848-A2 PHENETHYL-5-BROMOPYRIDYLTHIOUREA (PBT) AND DIHYDROALKOXYBENZYLOXOPYRIMIDINE (DABO) DERIVATIVES EXHIBITING SPERMICIDAL ACTIVITY Parker Hughes Institute (US) 2001-10-10 EP disclosed
US-6136335-A INHIBITING CONCEPTION IN A MAMMAL BY CONTACTING SPERM WITH A COMPOUND OF GIVEN FORMULA, SUCH AS N-(2-(2-FLUOROPHENETHYL))-N'-(2-(5-BROMOPYRIDYL))-THIOUREA HUGHES INSTITUTE (US) 2000-10-24 US disclosed
WO-2000061566-A1 PROCESS FOR PREPARING MKC-442 TRIANGLE PHARMACEUTICALS, INC. (US) 2000-10-19 WO disclosed
WO-2000061566-A1 PROCESS FOR PREPARING MKC-442 TRIANGLE PHARMACEUTICALS, INC. (US) 2000-10-19 WO disclosed
WO-2000039095-A2 PHENETHYL-5-BROMOPYRIDYLTHIOUREA (PBT) AND DIHYDROALKOXYBENZYLOXOPYRIMIDINE (DABO) DERIVATIVES EXHIBITING SPERMICIDAL ACTIVITY PARKER HUGHES INSTITUTE (US) 2000-07-06 WO disclosed