Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | PSEN1 | P49768 | 11/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287442 | 0.75 | HTT (0.48) | ALDH1A1KMT2AHTTPSEN1PSEN2 | |
| SCHEMBL27900246 | 0.69 | ALDH1A1 (0.59) | ALDH1A1KMT2AGAAHPGDHTT | |
| SCHEMBL12228299 | 0.68 | KMT2A (0.54) | ALDH1A1KMT2AGAAHPGDHTT | |
| SCHEMBL24254279 | 0.68 | KMT2A (0.56) | ALDH1A1KMT2AGAAHPGDHTT | |
| SCHEMBL5074436 | 0.67 | PSEN1 (1.00) | ALDH1A1KMT2AGAAHPGDHTT | |
| SCHEMBL14207992 | 0.67 | PSEN1 (0.72) | ALDH1A1KMT2AGAAHPGDHTT | |
| SCHEMBL682128 | 0.66 | MAPT (0.63) | ALDH1A1KMT2AGAAHPGDHTT | |
| SCHEMBL15396075 | 0.66 | CA2 (0.37) | — | |
| SCHEMBL4491616 | 0.66 | KMT2A (0.54) | ALDH1A1KMT2AGAAHPGDHTT | |
| SCHEMBL3808332 | 0.66 | USP30 (0.60) | ALDH1A1KMT2AGAAHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130310384-A1 | Sulfonamide-Containing Compounds | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2013-11-21 | — | — | US | disclosed |
| WO-2012047926-A2 | SULFONAMIDE-CONTAINING COMPOUNDS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310384-A1 | Sulfonamide-Containing Compounds | BACE1, BACE2, GSAP | ALDH1A1 3025/4885KMT2A 1318/4885GAA 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.