⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8155628 | 0.79 | MAOA (0.34) | — | |
| SCHEMBL10716988 | 0.77 | — | — | |
| SCHEMBL5652848 | 0.75 | — | — | |
| SCHEMBL97740 | 0.75 | — | — | |
| SCHEMBL2306127 | 0.75 | — | — | |
| SCHEMBL8776803 | 0.75 | — | — | |
| SCHEMBL919863 | 0.73 | MAOA (0.45) | — | |
| SCHEMBL27316073 | 0.72 | MAOA (0.47) | — | |
| SCHEMBL28235092 | 0.71 | — | — | |
| SCHEMBL6860279 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368470-B2 | Substituted 3-pyrrolidine-indole derivatives | GRUENENTHAL GMBH (DE) | 2008-05-06 | — | — | US | claimed |
| EP-1487809-B1 | PROCESS FOR THE PREPARATION OF MORPHOLINE DERIVATIVES AND INTERMEDIATES THEREFORE | GLAXO GROUP LTD (GB) | 2008-01-09 | — | — | EP | claimed |
| JP-2007501828-A | — | — | 2007-02-01 | — | — | JP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2006-05-10 | — | — | EP | claimed |
| US-20050096376-A1 | Substituted 3-pyrrolidine-indole derivatives | GRUENENTHAL GMBH (DE) | 2005-05-05 | — | — | US | claimed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | claimed |
| US-9301929-B2 | Substituted biaryl derivatives and methods of use thereof | MERCK SHARP & DOHME CORP. (US) | 2016-04-05 | — | — | US | disclosed |
| WO-2015040141-A1 | CYCLOBUTYLCARBOXAMIDES AS NEMATICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-03-26 | — | — | WO | disclosed |
| US-8907095-B2 | Bicyclic heterocycle derivatives and their use as modulators of the activity of GPR119 | MERCK SHARP & DOHME CORP. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20130310384-A1 | Sulfonamide-Containing Compounds | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2013-11-21 | — | — | US | disclosed |
| EP-2503887-A1 | SUBSTITUTED BIARYL DERIVATIVES AND METHODS OF USE THEREOF | Merck Sharp & Dohme Corp. (US) | 2012-10-03 | — | — | EP | disclosed |
| US-20120220614-A1 | SUBSTITUTED BIARYL DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC | 2012-08-30 | — | — | US | disclosed |
| US-20040058907-A1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | US | disclosed |
| WO-2003082835-A1 | PROCESS FOR THE PREPARATION OF MORPHOLINE DERIVATIVES AND INTERMEDIATES THEREFORE | GLAXO GROUP LIMITED (GB) | 2003-10-09 | — | — | WO | disclosed |
| EP-1324991-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002026723-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2002-04-04 | — | — | WO | disclosed |
| CN-1024317-C | Antifungal agents based on amides containing phenyl group | RHONE POULENC AGROCHIMIE (FR) | 1994-04-27 | — | — | CN | disclosed |
| CN-1040792-A | ANTIFUNGAL AGENTS BASED ON AMIDES CONTAINING PHENYL GROUP | RHONE POULENC AGROCHIMIE (FR) | 1990-03-28 | — | — | CN | disclosed |
| US-4282246-A | Antidiabetic furancarboxylic and thiphenecarboxylic acids | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |