Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10447516 | 0.91 | TAAR1 (0.70) | ALDH1A1TP53GAACYP19A1TAAR1 | |
| SCHEMBL4512796 | 0.86 | ALDH1A1 (0.72) | ALDH1A1TP53GAATAAR1HSD17B10 | |
| SCHEMBL407477 | 0.85 | ALDH1A1 (1.00) | ALDH1A1TP53GAATAAR1HSD17B10 | |
| SCHEMBL9661410 | 0.84 | CYP19A1 (0.58) | ALDH1A1TP53GAACYP19A1TBXAS1 | |
| SCHEMBL1287382 | 0.84 | TAAR1 (0.82) | ALDH1A1TP53GAACYP19A1TAAR1 | |
| SCHEMBL1287424 | 0.83 | ALDH1A1 (0.64) | ALDH1A1TP53GAATAAR1HSD17B10 | |
| SCHEMBL4517737 | 0.83 | ALDH1A1 (0.68) | ALDH1A1TP53GAATAAR1HSD17B10 | |
| SCHEMBL4517775 | 0.82 | ALDH1A1 (0.67) | ALDH1A1TP53GAATAAR1HSD17B10 | |
| SCHEMBL13889021 | 0.82 | ALDH1A1 (0.81) | ALDH1A1TP53GAATAAR1HSD17B10 | |
| SCHEMBL1954496 | 0.82 | CYP19A1 (0.80) | ALDH1A1CYP19A1KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047926-A2 | SULFONAMIDE-CONTAINING COMPOUNDS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2012-04-12 | — | — | WO | disclosed |