SCHEMBL128749

SCHEMBL128749

CCOC(Cl)[Si](C)(C)C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31296245 0.67 THRB (0.50)
SCHEMBL10354636 0.67
SCHEMBL868797 0.67
SCHEMBL15569527 0.67 THRB (0.36)
SCHEMBL29042409 0.67 THRB (0.36)
SCHEMBL6660324 0.67 THRB (0.36)
SCHEMBL29042410 0.67 THRB (0.36)
SCHEMBL29057527 0.67
SCHEMBL195701 0.65
SCHEMBL8319541 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 946 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025059723-A1 NOVEL INDOLE-BASED INTERMEDIATES AND PROCESSES FOR THEIR PRODUCTION Mynd Bio Pty Ltd (AU) 2025-03-27 WO claimed
CN-117720543-A Preparation method of barytinib 东北林业大学 2024-03-19 CN claimed
WO-2022238500-A1 RADIOSYNTHESIS OF [18F] TALAZOPARIB EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) 2022-11-17 WO claimed
EP-4089093-A1 RADIOSYNTHESIS OF [18F] TALAZOPARIB Eberhard Karls Universität Tübingen Medizinische Fakultät (DE) 2022-11-16 EP claimed
EP-0070588-B1 METHOD OF PREPARING 1-ALPHA-HYDROXYVITAMIN D AND 1-ALPHA-HYDROXY-PREVITAMIN D COMPOUNDS, AND ADDUCT OF A PREVITAMIN D OR TACHYSTEROL COMPOUND WITH A SUITABLE DIENOPHILE DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1986-05-07 EP claimed
US-4539153-A Method of preparing 1 α-hydroxyvitamin D and 1 α-hydroxyprevitamin D compounds, and adducts of a previtamin D or tachysterol compound with a suitable dienophile DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1985-09-03 US claimed
EP-0070588-A1 Method of preparing 1-alpha-hydroxyvitamin D and 1-alpha-hydroxy-previtamin D compounds, and adduct of a previtamin D or tachysterol compound with a suitable dienophile DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1983-01-26 EP claimed
US-20260098020-A1 HERBICIDAL PYRIMIDINYLMETHYL-SUBSTITUTED 1,2,4-TRIAZOLES FMC CORP (US) 2026-04-09 US disclosed
EP-3558298-B1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS MERCK SHARP & DOHME LLC (US) 2026-03-11 EP disclosed
US-12534463-B2 Substituted tricyclic compounds as FGFR inhibitors INCYTE CORPORATION (US) 2026-01-27 US disclosed
US-20250340559-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE HOLDINGS CORP (US) 2025-11-06 US disclosed
US-20250313575-A1 MACROCYCLES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF MERCK SHARP & DOHME LLC (US) 2025-10-09 US disclosed
EP-2958562-B1 ANTIDIABETIC BICYCLIC COMPOUNDS MERCK SHARP & DOHME LLC (US) 2025-09-10 EP disclosed
US-4959495-A Process for the preparation of intermediates used to produce aminothiazoloximino cephalosporins AMERICAN CYANAMID COMPANY (US) 1990-09-25 US disclosed
EP-0275997-A1 3(2H)pyridazinone, process for its preparation and antagonistic agent against SRS-A containing it NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1988-07-27 EP disclosed
EP-0257275-A2 Cephalosporin and penicillin derivatives AMERICAN CYANAMID COMPANY (US) 1988-03-02 EP disclosed
EP-0229922-A2 Novel 2,2'-BI-1H-imidazoles MERRELL DOW PHARMACEUTICALS INC. (US) 1987-07-29 EP disclosed
EP-0070588-B1 METHOD OF PREPARING 1-ALPHA-HYDROXYVITAMIN D AND 1-ALPHA-HYDROXY-PREVITAMIN D COMPOUNDS, AND ADDUCT OF A PREVITAMIN D OR TACHYSTEROL COMPOUND WITH A SUITABLE DIENOPHILE DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1986-05-07 EP disclosed
US-4539153-A Method of preparing 1 α-hydroxyvitamin D and 1 α-hydroxyprevitamin D compounds, and adducts of a previtamin D or tachysterol compound with a suitable dienophile DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1985-09-03 US disclosed
EP-0070588-A1 Method of preparing 1-alpha-hydroxyvitamin D and 1-alpha-hydroxy-previtamin D compounds, and adduct of a previtamin D or tachysterol compound with a suitable dienophile DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1983-01-26 EP disclosed