Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10354636 | 0.76 | — | — | |
| SCHEMBL8674568 | 0.70 | LMNA (0.58) | THRBLMNA | |
| SCHEMBL129287 | 0.69 | — | — | |
| SCHEMBL10517608 | 0.69 | — | — | |
| SCHEMBL8402515 | 0.68 | THRB (0.36) | THRBLMNA | |
| SCHEMBL16180649 | 0.68 | THRB (0.36) | THRBLMNA | |
| SCHEMBL196146 | 0.67 | THRB (0.31) | THRB | |
| SCHEMBL9405046 | 0.67 | — | — | |
| SCHEMBL5493890 | 0.67 | — | — | |
| SCHEMBL128749 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836490-B1 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER (US) | 2017-06-14 | — | — | EP | disclosed |
| US-9394285-B2 | Indole and indazole compounds that activate AMPK | PFIZER INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20160016940-A1 | Indole and Indazole Compounds that Activate AMPK | PFIZER, INC. (US) | 2016-01-21 | — | — | US | disclosed |
| EP-2970177-A1 | INDOLE COMPOUNDS THAT ACTIVATE AMPK | Pfizer Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2836490-A2 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | Pfizer Inc. (US) | 2015-02-18 | — | — | EP | disclosed |
| US-20150038484-A1 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER INC. (US) | 2015-02-05 | — | — | US | disclosed |
| US-8889730-B2 | Indole and indazole compounds that activate AMPK | PFIZER INC. (US) | 2014-11-18 | — | — | US | disclosed |
| WO-2014140704-A1 | INDOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2013153479-A2 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER INC. (US) | 2013-10-17 | — | — | WO | disclosed |
| US-20130267493-A1 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER INC. (US) | 2013-10-10 | — | — | US | disclosed |
| EP-1157001-B1 | OXAMIC ACIDS AND DERIVATIVES AS THYROID RECEPTOR LIGANDS | PFIZER PROD INC (US) | 2004-08-04 | — | — | EP | disclosed |
| US-20030114521-A1 | Oxamic acids and derivatives as thyroid receptor ligands | CHIANG YUAN-CHING PHOEBE (US) | 2003-06-19 | — | — | US | disclosed |
| US-6545018-B2 | Treating obesity, hyperlipidemia, glaucoma, arrhythmia, skin disorders, thyroid disease, hypothyroidism, diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression and osteoporosis | PFIZER INC. | 2003-04-08 | — | — | US | disclosed |
| US-20020049226-A1 | Oxamic acids and derivatives as thyroid receptor ligands | CHIANG YUAN-CHING PHOEBE (US) | 2002-04-25 | — | — | US | disclosed |
| US-6326398-B1 | Oxamic acids and derivatives as thyroid receptor ligands | PFIZER INC. | 2001-12-04 | — | — | US | disclosed |
| EP-1157001-A1 | OXAMIC ACIDS AND DERIVATIVES AS THYROID RECEPTOR LIGANDS | Pfizer Products Inc. (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051971-A1 | OXAMIC ACIDS AND DERIVATIVES AS THYROID RECEPTOR LIGANDS | PFIZER PRODUCTS INC. (US) | 2000-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114521-A1 | Oxamic acids and derivatives as thyroid receptor ligands | OXER1, THRA, TSHR | THRB 4/4885LMNA 3196/4885 |
| US-20160016940-A1 | Indole and Indazole Compounds that Activate AMPK | PRKAG1, PRKAG3, PRKAG2 | THRB 555/4885LMNA 3115/4885 |
| US-20020049226-A1 | Oxamic acids and derivatives as thyroid receptor ligands | OXER1, THRA, OXGR1 | THRB 4/4885LMNA 3176/4885 |
| US-20150038484-A1 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PRKAG1, PRKAG3, PRKAG2 | THRB 555/4885LMNA 3115/4885 |
| US-20130267493-A1 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PRKAG1, PRKAG3, PRKAG2 | THRB 555/4885LMNA 3115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.