Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | UBE2M | P61081 | 4/20 | 0.48 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875465 | 0.84 | RAB9A (0.63) | KDM4EPTGER4MEN1KMT2AALDH1A1 | |
| SCHEMBL1199346 | 0.83 | KDM4E (0.68) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL12875525 | 0.82 | MEN1 (0.52) | KDM4EPTGER4MEN1KMT2AALDH1A1 | |
| SCHEMBL14196468 | 0.82 | RAB9A (0.60) | KDM4EPTGER4MEN1KMT2AALDH1A1 | |
| SCHEMBL14224567 | 0.81 | PTGER4 (0.51) | KDM4EPTGER4MEN1KMT2AALDH1A1 | |
| SCHEMBL6255206 | 0.81 | RAB9A (0.58) | KDM4EPTGER4MEN1KMT2AALDH1A1 | |
| SCHEMBL12875489 | 0.79 | KDM4E (0.60) | KDM4EPTGER4MEN1KMT2AALDH1A1 | |
| SCHEMBL12875471 | 0.79 | RAB9A (0.72) | KDM4EPTGER4MEN1KMT2AALDH1A1 | |
| SCHEMBL12875498 | 0.79 | RAB9A (0.71) | KDM4EPTGER4MEN1KMT2AALDH1A1 | |
| SCHEMBL4823256 | 0.78 | KDM4E (0.65) | KDM4EPTGER4MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461348-B2 | Heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | PDE3B, PDE5A, PDE2A | KDM4E 1877/4885UBE2M 4764/4885DCUN1D1 3392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.