Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12875465 | 0.86 | RAB9A (0.63) | PTGER4KDM4EHPGDL3MBTL1RAB9A | |
| SCHEMBL12875552 | 0.86 | KMT2A (0.56) | PTGER4KDM4EHPGDL3MBTL1POLB | |
| SCHEMBL4827453 | 0.85 | KDM4E (0.54) | PTGER4KDM4EHPGDL3MBTL1POLB | |
| SCHEMBL14196468 | 0.84 | RAB9A (0.60) | PTGER4KDM4EHPGDL3MBTL1RAB9A | |
| SCHEMBL12875575 | 0.82 | PTGER1 (0.47) | PTGER4KDM4EHPGDL3MBTL1POLB | |
| SCHEMBL12875464 | 0.81 | KDM4E (0.51) | PTGER4KDM4EPOLBRAB9ANPC1 | |
| SCHEMBL6255206 | 0.81 | RAB9A (0.58) | PTGER4KDM4EHPGDL3MBTL1RAB9A | |
| SCHEMBL4827487 | 0.81 | PTGER4 (0.77) | PTGER4KDM4EHPGDL3MBTL1RAB9A | |
| SCHEMBL12875565 | 0.80 | KDM4E (0.45) | PTGER4KDM4EHPGDL3MBTL1POLB | |
| SCHEMBL12875489 | 0.79 | KDM4E (0.60) | PTGER4KDM4EHPGDL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |