Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12876132 | 0.92 | L3MBTL1 (0.38) | L3MBTL1GAAAKT1CNKSR1ADORA3 | |
| SCHEMBL1198270 | 0.91 | ALDH1A1 (0.41) | L3MBTL1GAAAKT1CNKSR1ADORA3 | |
| SCHEMBL1198271 | 0.91 | ALDH1A1 (0.41) | L3MBTL1GAAAKT1CNKSR1ADORA3 | |
| SCHEMBL1198725 | 0.90 | KDM4E (0.42) | L3MBTL1GAAAKT1CNKSR1ADORA3 | |
| SCHEMBL1198724 | 0.90 | KDM4E (0.42) | L3MBTL1GAAAKT1CNKSR1ADORA3 | |
| SCHEMBL12875965 | 0.89 | GRM2 (0.40) | L3MBTL1GAAAKT1CNKSR1MAPK1 | |
| SCHEMBL12876272 | 0.87 | MAPK1 (0.42) | L3MBTL1GAAAKT1CNKSR1MAPK1 | |
| SCHEMBL1198349 | 0.85 | ALDH1A1 (0.49) | L3MBTL1GAAAKT1CNKSR1MAPK1 | |
| SCHEMBL12875991 | 0.85 | MAPT (0.49) | L3MBTL1GAAAKT1CNKSR1MAPK1 | |
| SCHEMBL12875967 | 0.84 | GRM2 (0.42) | L3MBTL1GAAAKT1CNKSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461348-B2 | Heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | PDE3B, PDE5A, PDE2A | L3MBTL1 4726/4885GAA 2090/4885AKT1 402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.