Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TGM2 | P21980 | 3/20 | 0.45 |
| ▸ | F13A1 | P00488 | 1/20 | 0.45 |
| ▸ | TGM1 | P22735 | 1/20 | 0.45 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13923719 | 0.87 | ACE (0.63) | PREPACEDPP4DPP8ALDH1A1 | |
| SCHEMBL8603071 | 0.82 | DPP4 (0.58) | DPP4DPP8TGM2F13A1TGM1 | |
| SCHEMBL12253517 | 0.80 | REN (0.48) | PREPACEDPP4DPP8TGM2 | |
| SCHEMBL17497320 | 0.80 | L3MBTL1 (0.46) | DPP4DPP8L3MBTL1USP2 | |
| SCHEMBL21318202 | 0.79 | ACE (0.51) | PREPACEDPP4DPP8CTSK | |
| SCHEMBL12874098 | 0.78 | PREP (0.42) | PREPACEDPP4DPP8L3MBTL1 | |
| SCHEMBL11924566 | 0.77 | SYK (0.42) | L3MBTL1TGM2F13A1TGM1USP2 | |
| SCHEMBL924114 | 0.76 | PPARA (0.53) | CTSKCTSLCTSSCASP1 | |
| SCHEMBL924112 | 0.76 | PPARA (0.53) | CTSKCTSLCTSSCASP1 | |
| SCHEMBL1162401 | 0.76 | PPARA (0.53) | CTSKCTSLCTSSCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499148-B1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2017-01-18 | — | — | EP | disclosed |
| EP-2462147-B1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2014-11-12 | — | — | EP | disclosed |
| WO-2011015241-A1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2011-02-10 | — | — | WO | disclosed |