Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30386564 | 0.83 | KDM4E (0.42) | KDM4EHTTALDH1A1HPGDHSD17B10 | |
| SCHEMBL13504657 | 0.78 | SIRT1 (0.40) | KDM4EALDH1A1HPGDHSD17B10PDE4A | |
| SCHEMBL7282937 | 0.71 | ADORA1 (0.65) | ADORA2AADORA2BADORA1 | |
| SCHEMBL9406533 | 0.71 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL9927457 | 0.68 | PDE1A (0.66) | HTTMEN1KMT2APDE4APDE4B | |
| SCHEMBL9159465 | 0.68 | ADORA2B (0.66) | KDM4EALDH1A1HPGDHSD17B10CYP2C9 | |
| SCHEMBL9159455 | 0.68 | ADORA2B (0.66) | KDM4EALDH1A1HPGDHSD17B10CYP2C9 | |
| SCHEMBL7358457 | 0.66 | KDM4E (0.46) | KDM4EHTTALDH1A1HPGDHSD17B10 | |
| SCHEMBL13504712 | 0.65 | SIRT1 (0.42) | KDM4EALDH1A1HPGDHSD17B10PDE4A | |
| SCHEMBL3368846 | 0.65 | POLB (0.69) | KDM4EALDH1A1HSD17B10GAAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011022638-A1 | TRP INHIBITORS AND USES THEREOF | TRANSPOSAGEN BIOPHARMACEUTICALS, INC. (US) | 2011-02-24 | — | — | WO | disclosed |