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Sugi Predict / Compounds / Hygromycin A

Hygromycin A

Hygromycin A

SCHEMBL1287900

CC(=O)[C@H]1O[C@@H](Oc2ccc(/C=C(\C)C(=O)N[C@H]3[C@@H](O)[C@H](O)[C@@H]4OCO[C@@H]4[C@H]3O)cc2O)[C@@H](O)[C@@H]1O.COc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N(C)C)ncnc43)O[C@@H]2CO)cc1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ NPEPPS P55786 12/20 0.64
▸ ANPEP P15144 10/20 0.64
▸ SMN1; SMN2 Q16637 3/20 0.64
▸ TP53 P04637 2/20 0.64
▸ CYP3A4 P08684 2/20 0.64
▸ LMNA P02545 1/20 0.64
▸ HIF1A Q16665 1/20 0.64
▸ HTT P42858 1/20 0.63
▸ NPC1 O15118 1/20 0.63
▸ RAB9A P51151 1/20 0.63
▸ PAX8 Q06710 1/20 0.63
▸ TRDMT1 O14717 1/20 0.37
▸ ATM Q13315 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Puromycin SCHEMBL14583797 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL22348910 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL3042415 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL14583945 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL21306559 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL24206459 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL20815730 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL21481061 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL22409382 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4
Puromycin SCHEMBL20393806 0.80 NPEPPS (1.00) NPEPPSANPEPSMN1; SMN2TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2625277-B1 EXPRESSION VECTOR FOR HIGH LEVEL EXPRESSION OF RECOMBINANT PROTEINS CADILA HEALTHCARE LTD (IN) 2017-09-06 — — EP disclosed
US-20130244280-A1 EXPRESSION VECTOR FOR HIGH LEVEL EXPRESSION OF RECOMBINANT PROTEINS CADILA HEALTHCARE LIMITED (IN) 2013-09-19 — — US disclosed
EP-2625277-A2 EXPRESSION VECTOR FOR HIGH LEVEL EXPRESSION OF RECOMBINANT PROTEINS Cadila Healthcare Limited (IN) 2013-08-14 — — EP disclosed
WO-2012046255-A2 EXPRESSION VECTOR FOR HIGH LEVEL EXPRESSION OF RECOMBINANT PROTEINS CADILA HEALTHCARE LIMITED (IN) 2012-04-12 — — WO disclosed