Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | EIF4E | P06730 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TOP1 | P11387 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | PNP | P00491 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 7/20 | 0.38 |
| ▸ | CA2 | P00918 | 7/20 | 0.38 |
| ▸ | CA9 | Q16790 | 7/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12892511 | 0.89 | LMNA (0.52) | LMNASMN1; SMN2ALDH1A1ADORA1GLA | |
| SCHEMBL3313120 | 0.89 | LMNA (0.52) | LMNASMN1; SMN2ALDH1A1ADORA1GLA | |
| SCHEMBL15031302 | 0.89 | LMNA (0.52) | LMNASMN1; SMN2ALDH1A1ADORA1GLA | |
| SCHEMBL3313109 | 0.89 | LMNA (0.52) | LMNASMN1; SMN2ALDH1A1ADORA1GLA | |
| SCHEMBL13614201 | 0.89 | LMNA (0.52) | LMNASMN1; SMN2ALDH1A1ADORA1GLA | |
| SCHEMBL12300734 | 0.85 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1ADORA1GLA | |
| SCHEMBL12879162 | 0.81 | LMNA (0.40) | LMNASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL12150456 | 0.81 | LMNA (0.40) | LMNASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL12150452 | 0.79 | LMNA (0.79) | LMNASMN1; SMN2ALDH1A1ADORA1GLA | |
| SCHEMBL15019611 | 0.79 | LMNA (0.79) | LMNASMN1; SMN2ALDH1A1ADORA1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9149538-B2 | Oligomer conjugates of heteropentacyclic nucleosides | NEKTAR THERAPEUTICS (US) | 2015-10-06 | — | — | US | disclosed |
| US-20140288295-A1 | OLIGOMER CONJUGATES OF HETEROPENTACYCLIC NUCLEOSIDES | NEKTAR THERAPEUTICS | 2014-09-25 | — | — | US | disclosed |
| US-8778898-B2 | Oligomer conjugates of heteropentacyclic nucleosides | NEKTAR THERAPEUTICS (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130261072-A1 | OLIGOMER CONJUGATES OF HETEROPENTACYCLIC NUCLEOSIDES | NEKTAR THERAPEUTICS (US) | 2013-10-03 | — | — | US | disclosed |
| US-8466276-B2 | Oligomer conjugates of heteropentacyclic nucleosides | NEKTAR THERAPEUTICS (US) | 2013-06-18 | — | — | US | disclosed |
| US-20110039797-A1 | Oligomer Conjugates of Heteropentacyclic Nucleosides | Nektar Therapetics (US) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039797-A1 | Oligomer Conjugates of Heteropentacyclic Nucleosides | SLC29A2, SLC29A1, GNE | LMNA 3873/4885SMN1; SMN2 2799/4885ALDH1A1 2313/4885 |
| US-20140288295-A1 | OLIGOMER CONJUGATES OF HETEROPENTACYCLIC NUCLEOSIDES | SLC29A2, SLC29A1, GNE | LMNA 3873/4885SMN1; SMN2 2799/4885ALDH1A1 2313/4885 |
| US-20130261072-A1 | OLIGOMER CONJUGATES OF HETEROPENTACYCLIC NUCLEOSIDES | GNE, SLC29A2, ABCG2 | LMNA 3345/4885SMN1; SMN2 2130/4885ALDH1A1 2749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.