Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 11/20 | 0.38 |
| ▸ | CA2 | P00918 | 11/20 | 0.38 |
| ▸ | CA9 | Q16790 | 11/20 | 0.38 |
| ▸ | CA12 | O43570 | 9/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 9/20 | 0.38 |
| ▸ | CD69 | Q07108 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12150456 | 1.00 | LMNA (0.40) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL12154623 | 0.91 | CD69 (0.44) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL15031303 | 0.90 | LMNA (0.51) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL12892515 | 0.90 | LMNA (0.51) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL1377520 | 0.90 | LMNA (0.51) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL13614200 | 0.90 | LMNA (0.51) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL16349578 | 0.85 | OGA (0.36) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL14036675 | 0.85 | LMNA (0.34) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL12879161 | 0.81 | LMNA (0.54) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL12150458 | 0.77 | LMNA (0.45) | LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9149538-B2 | Oligomer conjugates of heteropentacyclic nucleosides | NEKTAR THERAPEUTICS (US) | 2015-10-06 | — | — | US | disclosed |
| US-20140288295-A1 | OLIGOMER CONJUGATES OF HETEROPENTACYCLIC NUCLEOSIDES | NEKTAR THERAPEUTICS | 2014-09-25 | — | — | US | disclosed |
| US-8778898-B2 | Oligomer conjugates of heteropentacyclic nucleosides | NEKTAR THERAPEUTICS (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130261072-A1 | OLIGOMER CONJUGATES OF HETEROPENTACYCLIC NUCLEOSIDES | NEKTAR THERAPEUTICS (US) | 2013-10-03 | — | — | US | disclosed |
| US-8466276-B2 | Oligomer conjugates of heteropentacyclic nucleosides | NEKTAR THERAPEUTICS (US) | 2013-06-18 | — | — | US | disclosed |
| US-20110039797-A1 | Oligomer Conjugates of Heteropentacyclic Nucleosides | Nektar Therapetics (US) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039797-A1 | Oligomer Conjugates of Heteropentacyclic Nucleosides | SLC29A2, SLC29A1, GNE | LMNA 3873/4885ALDH1A1 2313/4885TP53 891/4885 |
| US-20140288295-A1 | OLIGOMER CONJUGATES OF HETEROPENTACYCLIC NUCLEOSIDES | SLC29A2, SLC29A1, GNE | LMNA 3873/4885ALDH1A1 2313/4885TP53 891/4885 |
| US-20130261072-A1 | OLIGOMER CONJUGATES OF HETEROPENTACYCLIC NUCLEOSIDES | GNE, SLC29A2, ABCG2 | LMNA 3345/4885ALDH1A1 2749/4885TP53 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.