Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | FABP1 | P07148 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LIFR | P42702 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12879004 | 0.83 | NR1H4 (0.41) | NR1H4 | |
| SCHEMBL12879286 | 0.78 | NR1H4 (0.39) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL12188481 | 0.77 | NR1H4 (0.61) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL12879071 | 0.76 | NR1H4 (0.36) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL12879074 | 0.76 | NR1H4 (0.33) | NR1H4 | |
| SCHEMBL12879262 | 0.76 | NR1H4 (0.41) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL12188629 | 0.74 | NR1H4 (0.56) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL12879003 | 0.71 | NR1H4 (0.43) | NR1H4 | |
| SCHEMBL12879281 | 0.70 | NR1H4 (0.31) | NR1H4 | |
| SCHEMBL12879002 | 0.70 | NR1H4 (0.33) | NR1H4FABP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011020615-A1 | NOVEL FXR (NR1H4 ) BINDING AND ACTIVITY MODULATING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2011-02-24 | — | — | WO | disclosed |