Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12891770 | 1.00 | HSD11B1 (0.40) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14870541 | 0.78 | PSEN1 (0.47) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14870537 | 0.76 | PSEN1 (0.56) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4330555 | 0.71 | HSD11B1 (0.45) | HSD11B1CYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL13434491 | 0.70 | OPRM1 (0.33) | HSD11B1KCNH2 | |
| SCHEMBL13434490 | 0.70 | OPRM1 (0.33) | HSD11B1KCNH2 | |
| SCHEMBL12891947 | 0.68 | HSD11B1 (0.36) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12891958 | 0.67 | HSD11B1 (0.38) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9939512 | 0.65 | KMT2A (0.66) | HSD11B1ALDH1A1KMT2A | |
| SCHEMBL9938489 | 0.65 | KMT2A (0.66) | HSD11B1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7880009-B2 | Alzheimer's disease, senile dementia, Down syndrome or amyloidosis; (E)-N-biphenyl-3-ylmethyl-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)acrylamide for example; imidazolyl-functional compounds inhibit production of Amyloid beta 40 and Amyloid beta 42 | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-02-01 | — | — | US | disclosed |