Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4498518 | 0.99 | MKNK1 (0.39) | MKNK1PDE10AADORA2AADORA1VCP | |
| Hydrochloric Acid SCHEMBL4512248 | 0.85 | PDE10A (0.41) | MKNK1PDE10ASIRT6RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL4493037 | 0.83 | PDE10A (0.38) | PDE10ASIRT6RAB9AKDM4ETACR3 | |
| SCHEMBL1289370 | 0.73 | SIRT6 (0.38) | MKNK1PDE10AADORA2AADORA1SIRT6 | |
| SCHEMBL12473398 | 0.71 | PDE10A (0.37) | MKNK1PDE10AADORA2AADORA1SIRT6 | |
| Hydrochloric Acid SCHEMBL4512403 | 0.71 | PDE10A (0.38) | MKNK1PDE10ASIRT6RAB9AKDM4E | |
| SCHEMBL12473350 | 0.70 | PDE10A (0.39) | MKNK1PDE10ASIRT6RAB9AKDM4E | |
| SCHEMBL12473432 | 0.69 | PDE10A (0.36) | MKNK1PDE10AADORA2AADORA1SIRT6 | |
| SCHEMBL12473409 | 0.68 | PDE10A (0.35) | MKNK1PDE10ASIRT6RAB9AKDM4E | |
| SCHEMBL12473359 | 0.68 | SIRT6 (0.36) | MKNK1PDE10ASIRT6RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012046207-A1 | ANTI-PARASITIC SUBSTITUTED RING FUSED AZINE COMPOUNDS | PARACO TECHNOLOGY LIMITED (NZ) | 2012-04-12 | — | — | WO | disclosed |