Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CD38 | P28907 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4493832 | 0.85 | ALDH1A1 (0.50) | MKNK1ALDH1A1MAPK1RAD52KMT2A | |
| Hydrochloric Acid SCHEMBL4504952 | 0.84 | RAD52 (0.50) | MKNK1ALDH1A1MAPK1RAD52KMT2A | |
| SCHEMBL1289521 | 0.84 | ALDH1A1 (0.44) | MKNK1ALDH1A1MAPK1RAD52KMT2A | |
| Hydrochloric Acid SCHEMBL4505202 | 0.83 | ALDH1A1 (0.47) | MKNK1ALDH1A1MAPK1RAD52KMT2A | |
| SCHEMBL1289432 | 0.83 | CHRM2 (0.49) | MKNK1ALDH1A1MAPK1RAD52KMT2A | |
| SCHEMBL1289428 | 0.83 | MAPK1 (0.48) | MKNK1ALDH1A1MAPK1RAD52KMT2A | |
| SCHEMBL1289436 | 0.83 | MAPK1 (0.48) | MKNK1ALDH1A1MAPK1RAD52KMT2A | |
| Hydrochloric Acid SCHEMBL4498523 | 0.82 | MAPK1 (0.49) | MKNK1ALDH1A1MAPK1RAD52KMT2A | |
| Hydrochloric Acid SCHEMBL4493025 | 0.82 | MAPK1 (0.49) | MKNK1ALDH1A1MAPK1RAD52KMT2A | |
| Hydrochloric Acid SCHEMBL4508262 | 0.82 | RAD52 (0.48) | MKNK1ALDH1A1MAPK1RAD52KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318479-A1 | SUBSTITUTED RING FUSED AZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED | 2009-12-24 | — | — | US | claimed |
| WO-2012046207-A1 | ANTI-PARASITIC SUBSTITUTED RING FUSED AZINE COMPOUNDS | PARACO TECHNOLOGY LIMITED (NZ) | 2012-04-12 | — | — | WO | disclosed |
| US-20090318479-A1 | SUBSTITUTED RING FUSED AZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318479-A1 | SUBSTITUTED RING FUSED AZINES AND THEIR USE IN CANCER THERAPY | TP53, AZI2, MCL1 | MKNK1 1311/4885ALDH1A1 217/4885MAPK1 4692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.