Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1206989 | 0.90 | MAPT (0.43) | TP53MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL14293348 | 0.89 | LMNA (0.38) | TP53LMNAALPLALPIALPG | |
| SCHEMBL14292974 | 0.88 | TP53 (0.45) | TP53LMNAALPLALPIALPG | |
| SCHEMBL14293179 | 0.87 | ADORA2A (0.39) | TP53ALPLALPIALPGMAPT | |
| SCHEMBL14292407 | 0.86 | THRB (0.39) | TP53LMNAALPLALPIALPG | |
| SCHEMBL14293350 | 0.86 | MAPT (0.37) | TP53LMNAALPLALPIALPG | |
| SCHEMBL14292411 | 0.85 | MAPT (0.38) | TP53LMNAALPLALPIALPG | |
| SCHEMBL14293346 | 0.84 | MAPT (0.38) | TP53LMNAMAPTKMT2AMEN1 | |
| SCHEMBL14293352 | 0.84 | THRB (0.39) | TP53LMNAMAPTKMT2AMEN1 | |
| SCHEMBL12895467 | 0.84 | TP53 (0.38) | TP53LMNAALPLALPIALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110044938-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | NYCOMED GMBH (DE) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110044938-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | BAX, BCL2, BAD | TP53 46/4885LMNA 3666/4885ALPL 3555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.