Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | SCN4A | P35499 | 1/20 | 0.30 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12922998 | 0.82 | SMN1; SMN2 (0.38) | SMN1; SMN2RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL12896160 | 0.80 | ALB (0.38) | RAB9AMAPT | |
| SCHEMBL12896174 | 0.79 | CYP17A1 (0.36) | RAB9ANPC1MEN1KMT2A | |
| SCHEMBL12896159 | 0.79 | ICAM1 (0.42) | MAPTHPGD | |
| SCHEMBL12896179 | 0.73 | GPR3 (0.46) | SMN1; SMN2RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL11714081 | 0.73 | RAB9A (0.45) | SMN1; SMN2RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL12896171 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1MAPTHPGDEGFR | |
| SCHEMBL17232354 | 0.71 | UGT2B7 (0.35) | KDM4E | |
| SCHEMBL3887754 | 0.71 | MAPT (0.58) | SMN1; SMN2RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL30340804 | 0.71 | MAPT (0.58) | SMN1; SMN2RAB9AALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028507-A1 | PYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | CRYSTALGENOMICS, INC. (KR) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028507-A1 | PYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | EGLN3, EGLN2, HIF1A | SMN1; SMN2 1925/4885RAB9A 2270/4885ALDH1A1 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.