Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 8/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CCR2 | P41597 | 1/20 | 0.53 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12897454 | 0.99 | DRD2 (0.64) | DRD2MEN1KMT2AHTR7ATM | |
| SCHEMBL12897535 | 0.94 | DRD2 (0.69) | DRD2MEN1KMT2AHTR7ATM | |
| SCHEMBL12897167 | 0.88 | DRD2 (0.61) | DRD2MEN1KMT2AHTR7ATM | |
| SCHEMBL12896417 | 0.86 | DRD2 (0.56) | DRD2MEN1KMT2AHTR7ATM | |
| SCHEMBL12896482 | 0.85 | MEN1 (0.64) | DRD2MEN1KMT2AHTR7ATM | |
| SCHEMBL12897596 | 0.83 | DRD2 (0.59) | DRD2MEN1KMT2AHTR7ATM | |
| SCHEMBL8304330 | 0.82 | DRD2 (0.78) | DRD2MEN1KMT2AHTR7ATM | |
| SCHEMBL6505862 | 0.81 | DRD2 (0.71) | DRD2MEN1KMT2AHTR7ATM | |
| SCHEMBL12896664 | 0.80 | OPRM1 (0.53) | DRD2MEN1KMT2ACCR2DRD4 | |
| SCHEMBL6068249 | 0.80 | DRD2 (0.55) | DRD2MEN1KMT2AHTR7ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7880007-B2 | such as 1-bicyclo[2.2.1]hept-2-yl-4-(4-methoxy-2-methyl-phenyl)-piperidine, used for the treatment of chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects and Alzheimer's disease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |
| US-7880007-B2 | such as 1-bicyclo[2.2.1]hept-2-yl-4-(4-methoxy-2-methyl-phenyl)-piperidine, used for the treatment of chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects and Alzheimer's disease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |