Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12899183 | 0.89 | SIGMAR1 (0.39) | KCNH2SIGMAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL12899355 | 0.89 | SIGMAR1 (0.39) | KCNH2SIGMAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL12899253 | 0.86 | SIGMAR1 (0.37) | KCNH2CHRM4CHRM1SIGMAR1OPRM1 | |
| SCHEMBL12928365 | 0.85 | KCNH2 (0.36) | KCNH2CHRM4CHRM1SIGMAR1OPRM1 | |
| SCHEMBL12084523 | 0.85 | KCNH2 (0.36) | KCNH2CHRM4CHRM1SIGMAR1OPRM1 | |
| SCHEMBL12899290 | 0.82 | MCHR2 (0.41) | KCNH2CHRM4CHRM1 | |
| SCHEMBL12899340 | 0.82 | MCHR2 (0.41) | KCNH2CHRM4CHRM1 | |
| SCHEMBL12899386 | 0.82 | SIGMAR1 (0.39) | KCNH2CHRM4CHRM1SIGMAR1OPRM1 | |
| SCHEMBL13640967 | 0.78 | SIGMAR1 (0.35) | KCNH2CHRM4CHRM1SIGMAR1OPRM1 | |
| SCHEMBL12899155 | 0.77 | MCHR2 (0.51) | KCNH2SIGMAR1OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879834-B2 | spiro[indoline-3,4'-piperidine] derivatives, used for the treatment of nervous system disorders, chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects, Alzheimer's disiease, obesity or as analgesics and antidepressants | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |