Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.35 |
| ▸ | MCHR2 | Q969V1 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12899183 | 1.00 | SIGMAR1 (0.39) | SIGMAR1OPRL1OPRM1OPRK1HSD11B1 | |
| SCHEMBL12899253 | 0.90 | SIGMAR1 (0.37) | SIGMAR1OPRL1OPRM1OPRK1HSD11B1 | |
| SCHEMBL12899366 | 0.89 | KCNH2 (0.40) | SIGMAR1OPRL1OPRM1OPRK1KCNH2 | |
| SCHEMBL12293597 | 0.87 | SIGMAR1 (0.39) | SIGMAR1OPRL1OPRM1OPRK1MCHR2 | |
| SCHEMBL12199157 | 0.86 | SIGMAR1 (0.50) | SIGMAR1OPRL1OPRM1OPRK1DRD2 | |
| SCHEMBL12899386 | 0.85 | SIGMAR1 (0.39) | SIGMAR1OPRL1OPRM1OPRK1HSD11B1 | |
| SCHEMBL13641131 | 0.84 | HSD11B1 (0.36) | SIGMAR1OPRL1OPRM1OPRK1HSD11B1 | |
| SCHEMBL12084560 | 0.83 | OPRM1 (0.39) | SIGMAR1OPRL1OPRM1OPRK1HSD11B1 | |
| SCHEMBL12928366 | 0.83 | OPRM1 (0.39) | SIGMAR1OPRL1OPRM1OPRK1HSD11B1 | |
| SCHEMBL3548489 | 0.83 | OPRM1 (0.39) | SIGMAR1OPRL1OPRM1OPRK1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879834-B2 | spiro[indoline-3,4'-piperidine] derivatives, used for the treatment of nervous system disorders, chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects, Alzheimer's disiease, obesity or as analgesics and antidepressants | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |