Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 15/20 | 0.71 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 11/20 | 0.46 |
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1276374 | 0.93 | ADRB2 (0.81) | ADRB2CHRM3ADRB1DRD2ADRA1D | |
| SCHEMBL1276054 | 0.93 | ADRB2 (0.81) | ADRB2CHRM3ADRB1DRD2ADRA1D | |
| Fumaric Acid SCHEMBL2143201 | 0.90 | ADRB2 (0.77) | ADRB2CHRM3ADRB1DRD2ADRA1D | |
| Fumaric Acid SCHEMBL1276359 | 0.90 | ADRB2 (0.77) | ADRB2CHRM3ADRB1DRD2ADRA1D | |
| Fumaric Acid SCHEMBL2143189 | 0.90 | ADRB2 (0.77) | ADRB2CHRM3ADRB1DRD2ADRA1D | |
| Trifluoroacetic Acid SCHEMBL12095969 | 0.90 | ADRB2 (0.77) | ADRB2CHRM3ADRB1DRD2ADRA1D | |
| SCHEMBL10241928 | 0.89 | ADRB2 (0.74) | ADRB2CHRM3ADRB1DRD2ADRA1D | |
| SCHEMBL10242229 | 0.87 | ADRB2 (0.71) | ADRB2CHRM3ADRB1DRD2ADRA1D | |
| SCHEMBL10242789 | 0.86 | ADRB2 (0.72) | ADRB2CHRM3ADRB1DRD2ADRA1D | |
| SCHEMBL10241948 | 0.85 | ADRB2 (0.68) | ADRB2CHRM3ADRB1DRD2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2624838-A1 | NOVEL COMBINATIONS | AstraZeneca AB (SE) | 2013-08-14 | — | — | EP | disclosed |
| WO-2012046050-A1 | NOVEL COMBINATIONS | ASTRAZENECA AB (SE) | 2012-04-12 | — | — | WO | disclosed |