Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 12/20 | 0.77 |
| ▸ | CHRM3 known ✓ | P20309 | 9/20 | 0.77 |
| ▸ | CHRM2 known ✓ | P08172 | 8/20 | 0.51 |
| ▸ | ADRB1 known ✓ | P08588 | 8/20 | 0.45 |
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2143201 | 1.00 | ADRB2 (0.77) | ADRB2CHRM3CHRM2ADRB1DRD2 | |
| Fumaric Acid SCHEMBL2143189 | 1.00 | ADRB2 (0.77) | ADRB2CHRM3CHRM2ADRB1DRD2 | |
| SCHEMBL1276374 | 0.97 | ADRB2 (0.81) | ADRB2CHRM3CHRM2ADRB1DRD2 | |
| SCHEMBL1276054 | 0.97 | ADRB2 (0.81) | ADRB2CHRM3CHRM2ADRB1DRD2 | |
| Trifluoroacetic Acid SCHEMBL12095969 | 0.95 | ADRB2 (0.77) | ADRB2CHRM3CHRM2ADRB1DRD2 | |
| SCHEMBL10241928 | 0.93 | ADRB2 (0.74) | ADRB2CHRM3CHRM2ADRB1DRD2 | |
| SCHEMBL10242229 | 0.91 | ADRB2 (0.71) | ADRB2CHRM3CHRM2ADRB1DRD2 | |
| SCHEMBL10242789 | 0.90 | ADRB2 (0.72) | ADRB2CHRM3CHRM2ADRB1DRD2 | |
| SCHEMBL1289938 | 0.90 | ADRB2 (0.71) | ADRB2CHRM3CHRM2ADRB1DRD2 | |
| SCHEMBL10241948 | 0.89 | ADRB2 (0.68) | ADRB2CHRM3CHRM2ADRB1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242759-B1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | claimed |
| US-8629271-B2 | Compounds | ASTRAZENECA AB (GB) | 2014-01-14 | — | — | US | disclosed |
| US-20120322788-A1 | Compouds | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2012-12-20 | — | — | US | disclosed |
| EP-2242759-B1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |
| US-8148373-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-03 | — | — | US | disclosed |
| WO-2011012897-A1 | NEW COMBINATIONS FOR THE TREATMENT OF ASTHMA | ASTRAZENECA AB (SE) | 2011-02-03 | — | — | WO | disclosed |
| EP-2242759-A1 | COMPOUNDS | AstraZeneca AB (SE) | 2010-10-27 | — | — | EP | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
| WO-2009098448-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322788-A1 | Compouds | PKD1, SBDS, ABCB11 | ADRB2 1366/4885CHRM3 4265/4885CHRM2 3668/4885 |
| US-20090298807-A1 | Compounds | PKD1, SLC10A1, ABCB11 | ADRB2 218/4885CHRM3 2714/4885CHRM2 2419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.