Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.72 |
| ▸ | DRD3 | P35462 | 5/20 | 0.72 |
| ▸ | HTR2A | P28223 | 5/20 | 0.72 |
| ▸ | HTR2C | P28335 | 5/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.72 |
| ▸ | DRD1 | P21728 | 3/20 | 0.72 |
| ▸ | HRH1 | P35367 | 3/20 | 0.72 |
| ▸ | DRD4 | P21917 | 2/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.72 |
| ▸ | HTR1A | P08908 | 1/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.72 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.72 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.72 |
| ▸ | HTR2B | P41595 | 1/20 | 0.72 |
| ▸ | HTR3A | P46098 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1146208 | 0.91 | DRD2 (0.85) | DRD2DRD3HTR2AHTR2CADRA2A | |
| SCHEMBL12900466 | 0.87 | HTR2A (0.71) | DRD2DRD3HTR2AHTR2CADRA2A | |
| SCHEMBL12900469 | 0.85 | HTR2A (0.61) | DRD2DRD3HTR2AHTR2CADRA2A | |
| Asenapine SCHEMBL4060905 | 0.84 | DRD2 (1.00) | DRD2DRD3HTR2AHTR2CADRA2A | |
| Asenapine SCHEMBL3805507 | 0.84 | DRD2 (1.00) | DRD2DRD3HTR2AHTR2CADRA2A | |
| Asenapine SCHEMBL2221502 | 0.84 | DRD2 (1.00) | DRD2DRD3HTR2AHTR2CADRA2A | |
| Asenapine SCHEMBL8008417 | 0.84 | DRD2 (1.00) | DRD2DRD3HTR2AHTR2CADRA2A | |
| SCHEMBL13647032 | 0.84 | DRD1 (0.70) | DRD2DRD3HTR2AHTR2CADRA2A | |
| Asenapine SCHEMBL11537117 | 0.84 | DRD2 (1.00) | DRD2DRD3HTR2AHTR2CADRA2A | |
| Asenapine SCHEMBL114123 | 0.84 | DRD2 (1.00) | DRD2DRD3HTR2AHTR2CADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011012654-A1 | HYDROXYASENAPINE COMPOUNDS, DERIVATIVES THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | N.V. ORGANON (NL) | 2011-02-03 | — | — | WO | disclosed |