Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.50 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27782213 | 0.87 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL7840002 | 0.83 | GPR84 (0.47) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL28843981 | 0.83 | MAPT (0.46) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL27782223 | 0.82 | CTNNB1 (0.44) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL27829330 | 0.82 | PTPN1 (0.45) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL27928255 | 0.80 | CTNNB1 (0.43) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL27782246 | 0.80 | DHODH (0.43) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL28783987 | 0.79 | GRIN2D (0.46) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL30363668 | 0.79 | MEN1 (0.55) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL7554285 | 0.79 | MEN1 (0.55) | MEN1KMT2AALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2624838-A1 | NOVEL COMBINATIONS | AstraZeneca AB (SE) | 2013-08-14 | — | — | EP | disclosed |
| WO-2012085582-A1 | COMPOUND | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012085583-A1 | NEW COMPOUND | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012046050-A1 | NOVEL COMBINATIONS | ASTRAZENECA AB (SE) | 2012-04-12 | — | — | WO | disclosed |