Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP2 | P42575 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19849367 | 0.87 | ALDH1A1 (0.48) | CASP2NAAAALDH1A1FAAHTSHR | |
| SCHEMBL19880188 | 0.87 | CASP2 (0.52) | CASP2NAAAHIF1AKDM4EMAPK1 | |
| SCHEMBL19123954 | 0.84 | CASP2 (0.69) | CASP2NAAAMAPK1MEN1KMT2A | |
| SCHEMBL12302054 | 0.83 | CASP2 (0.55) | CASP2NAAAHIF1AKDM4EMAPK1 | |
| SCHEMBL25453230 | 0.83 | PAOX (0.52) | HIF1AKDM4EMAPK1ALDH1A1MEN1 | |
| SCHEMBL23729381 | 0.83 | PAOX (0.52) | HIF1AKDM4EMAPK1ALDH1A1MEN1 | |
| SCHEMBL25453657 | 0.83 | PAOX (0.52) | HIF1AKDM4EMAPK1ALDH1A1MEN1 | |
| SCHEMBL13311546 | 0.83 | PAOX (0.52) | HIF1AKDM4EMAPK1ALDH1A1MEN1 | |
| SCHEMBL25090250 | 0.83 | PAOX (0.52) | HIF1AKDM4EMAPK1ALDH1A1MEN1 | |
| SCHEMBL25453158 | 0.83 | PAOX (0.52) | HIF1AKDM4EMAPK1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476451-B2 | Tubulysin D analogues | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-07-02 | — | — | US | disclosed |
| US-20110021568-A1 | TUBULYSIN D ANALOGUES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021568-A1 | TUBULYSIN D ANALOGUES | TEK, NGLY1, TEKT1 | CASP2 3650/4885NAAA 2576/4885HIF1A 3275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.