Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 12/20 | 0.65 |
| ▸ | OPRK1 known ✓ | P41145 | 9/20 | 0.65 |
| ▸ | OPRD1 known ✓ | P41143 | 3/20 | 0.65 |
| ▸ | MRGPRX2 | Q96LB1 | 3/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL12905901 | 0.95 | OPRM1 (0.59) | OPRM1OPRK1MRGPRX2OPRD1ADRB1 | |
| Codeine SCHEMBL12905618 | 0.94 | OPRM1 (0.73) | OPRM1OPRK1MRGPRX2OPRD1ADRB1 | |
| Codeine SCHEMBL12905894 | 0.94 | OPRM1 (0.70) | OPRM1OPRK1MRGPRX2OPRD1ADRB1 | |
| Codeine SCHEMBL12905854 | 0.92 | OPRM1 (0.59) | OPRM1OPRK1MRGPRX2OPRD1ADRB1 | |
| Codeine SCHEMBL12906029 | 0.91 | OPRM1 (0.55) | OPRM1OPRK1MRGPRX2OPRD1ADRB1 | |
| Codeine SCHEMBL12906851 | 0.91 | OPRM1 (0.62) | OPRM1OPRK1MRGPRX2OPRD1ADRB1 | |
| Codeine SCHEMBL12905855 | 0.91 | OPRM1 (0.58) | OPRM1OPRK1MRGPRX2OPRD1ADRB1 | |
| Codeine SCHEMBL12905863 | 0.91 | OPRM1 (0.58) | OPRM1OPRK1MRGPRX2OPRD1ADRB1 | |
| Codeine SCHEMBL12905972 | 0.90 | OPRM1 (0.52) | OPRM1OPRK1MRGPRX2OPRD1ADRB1 | |
| Codeine SCHEMBL12905763 | 0.90 | OPRM1 (0.78) | OPRM1OPRK1MRGPRX2OPRD1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872013-B2 | Preparation and utility of opioid analgesics | AUSPEX PHARMACEUTICALS, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-20080045558-A1 | PREPARATION AND UTILITY OF OPIOID ANALGESICS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045558-A1 | PREPARATION AND UTILITY OF OPIOID ANALGESICS | OPRM1, OPRK1, OPRL1 | OPRM1 1/4885OPRK1 2/4885OPRD1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.