Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.66 |
| ▸ | JAK3 | P52333 | 5/20 | 0.59 |
| ▸ | TYK2 | P29597 | 4/20 | 0.56 |
| ▸ | PLK4 | O00444 | 3/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | MARK3 | P27448 | 3/20 | 0.56 |
| ▸ | CLK2 | P49760 | 3/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.56 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1142228 | 0.89 | JAK2 (0.64) | JAK2JAK3TYK2PLK4DAPK3 | |
| Hydrochloric Acid SCHEMBL1141989 | 0.88 | JAK2 (0.62) | JAK2JAK3TYK2PLK4DAPK3 | |
| SCHEMBL6479720 | 0.87 | JAK2 (0.66) | JAK2JAK3CDK2ROCK1AURKB | |
| SCHEMBL1690470 | 0.86 | JAK2 (0.55) | JAK2JAK3TYK2PLK4DAPK3 | |
| SCHEMBL28871206 | 0.86 | JAK2 (0.65) | JAK2JAK3TYK2PLK4DAPK3 | |
| SCHEMBL29968032 | 0.86 | JAK2 (0.65) | JAK2JAK3TYK2PLK4DAPK3 | |
| SCHEMBL10213929 | 0.84 | JAK2 (0.81) | JAK2JAK3TYK2PLK4DAPK3 | |
| SCHEMBL22339348 | 0.84 | JAK2 (0.51) | JAK2JAK3MITFALDH1A1TP53 | |
| SCHEMBL12907182 | 0.84 | JAK2 (0.69) | JAK2JAK3TYK2PLK4DAPK3 | |
| SCHEMBL11911445 | 0.83 | JAK2 (0.55) | JAK2JAK3TYK2PLK4DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260165-B | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2024-08-06 | — | — | CN | disclosed |
| CN-115260165-A | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-11-01 | — | — | CN | disclosed |
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |
| US-20070232620-A1 | 3-Aminoindazoles | MERCK PATENT GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| US-20070232620-A1 | 3-Aminoindazoles | MERCK PATENT GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232620-A1 | 3-Aminoindazoles | SGK3, SGK1, SGK2 | JAK2 562/4885JAK3 180/4885TYK2 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.