Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.65 |
| ▸ | JAK3 | P52333 | 4/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 2/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | MARK3 | P27448 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 2/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28871206 | 1.00 | JAK2 (0.65) | JAK2JAK3TYK2PDPK1JAK1 | |
| SCHEMBL12907189 | 0.86 | JAK2 (0.66) | JAK2JAK3TYK2PDPK1JAK1 | |
| SCHEMBL12907220 | 0.85 | JAK2 (0.65) | JAK2JAK3TYK2PDPK1JAK1 | |
| SCHEMBL1690470 | 0.82 | JAK2 (0.55) | JAK2JAK3TYK2PDPK1JAK1 | |
| SCHEMBL10213929 | 0.80 | JAK2 (0.81) | JAK2JAK3TYK2PDPK1JAK1 | |
| SCHEMBL12907221 | 0.80 | JAK2 (0.71) | JAK2JAK3TYK2PDPK1JAK1 | |
| SCHEMBL12907246 | 0.79 | JAK2 (1.00) | JAK2JAK3TYK2PDPK1JAK1 | |
| SCHEMBL3359889 | 0.79 | JAK2 (1.00) | JAK2JAK3TYK2PDPK1JAK1 | |
| SCHEMBL1142228 | 0.79 | JAK2 (0.64) | JAK2JAK3TYK2JAK1PLK4 | |
| SCHEMBL24126349 | 0.78 | KIF11 (0.59) | PDPK1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260165-B | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2024-08-06 | — | — | CN | disclosed |
| CN-115260165-A | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-11-01 | — | — | CN | disclosed |